The complete guide to CBDay Plus cannabinoids and terpenes effects

The hemp industry’s boom has been all about CBD cannabinoid products, from gummies to crystals, it seemed like all that Cannabis Sativa L. had to offer to the world was Cannabidiol!

Of course all players know that CBD is not the only cannabinoid you can find in Cannabis, there are plenty and we are still discovering new ones.

However, when the markets ask for apples, oranges are not as intriguing. Thus, everyone involved in the industry has been selling CBD-based products. 

There is one big issue with this approach though, and ignoring it may result, actually it is already resulting in, worrisome backlash. We did the same, for a while, but eventually we found a better long term strategy.

What is the nature of this issue and how can it be solved?

Creating an actual full spectrum cbd oil to trigger an actual entourage effect

The issue is that full spectrum has become a buzzword, and it should not have.

The full spectrum concept dates back to Mechoulam research and its work on the Entourage effect, i.e. the combined effect of the various types of cannabinoids, terpenes and flavonoids on the Endocannabinoid System.

One thing that is always neglected, usually for marketing purposes, is that a real full spectrum is such only when you have, well, the full spectrum of cannabinoids inside an extract, which means THC too.

Of course that is a no-no in the hemp industry, as THC, over 0.2% concentrations, is illegal in the EU.

What to do then?

You can still get an almost full spectrum without THC, by including well-researched Cannabinoids and terpenes. This will warrant an optimal entourage effect.

And that is what CBDay Plus, our premium extract, has been created for.

Compared to other alleged full spectrum cbd oils on the market, ours includes a wide range of cannabinoids and has a unique terpene profile.

To recap: extracts that only feature CBD cannot trigger a real entourage effect, even when they are labeled as full spectrum.

Our CBDay Plus features a carefully selected spectrum of natural compounds to activate a boosted entourage effect.

Let’s see each one of them and what it does.

CBDay Plus featured cannabinoids

If you want to know more about CBDay Plus, our brand new full spectrum extract, you can check the full guide, in this article we will focus on how each cannabinoid and terpene contributes to the desired effect, and why we chose this specific combination.

Cannabigerol (CBG)

This phytocannabinoid binds to both CB1 and CB2 receptors, enhancing the function of anandamide, an endocannabinoid neurotransmitter crucial in the regulation of pleasure, motivation, appetite, and pain. 

It has antibacterial, antimicrobial, and anti-inflammatory properties and can be useful in relieving both neuropathic and inflammatory pain, but more and more research is showing its usefulness in preventing and combating numerous issues, such as Inflammatory Bowel Diseases (IBD), glaucoma, Huntington’s disease, and even certain types of cancer.

Cannabinol (CBN)

A very interesting cannabinoid that binds exclusively to CB2 receptors. It has a molecular structure very similar to that of THC, this is because it originates at the final stage of the plant, through the maturation and oxidation of trichomes, resulting in the progressive degradation of THC into CBN. 

It turns out to be much more active and effective than its parent, about 25% more, with no psychoactive properties. Although the scientific literature on it is quite limited, its sedative properties, useful for sleep disorders, and the pain relief it brings, combined with CBD, in the treatment of muscle and joint pain are evident. 

Some studies have shown efficacy in delaying the onset of ALS, but further research is needed. 

Cannabichromene (CBC)

This cannabinoid, like THC and CBD, originates from CBGA. 

It lacks a psychoactive effect but is considered one of the cannabinoids with the most interesting therapeutic properties as it partly binds to CB1 receptors but much more effectively to other more peculiar receptors: the vanilloid receptor TRPV1 and the potential transient receptor ankyrin 1 (TRPA1), both of which are linked to pain perception. 

When these are stimulated by CBC, the production of natural endocannabinoids increases exponentially. The potential of CBC is yet to be discovered, but to date studies show its efficacy in preventing and fighting cancer (acting as an inhibitor of anandamide metabolism, which fights certain types of cancer in vitro and in vivo), in blocking pain and inflammation associated with collagen-induced osteoarthritis, in combating depression, acne, and especially in preventing neuronal degeneration. 

In fact, CBC has a positive effect on neural stem progenitor cells (NSPCs), an essential cell for healthy brain function. NSPCs become more viable in the presence of CBC, and this is promising because NSPCs include astroglial cells, the most important cells for maintaining brain homeostasis.  

Each cannabinoid has its own area of influence and benefits, to prevent or address certain issues. It follows that a synergistic action of several cannabinoids working simultaneously is definitely more effective and decisive. 

So, less CBD and more altcannabinoids! 

But, what about terpenes? 

Well, they are an integral part of the entourage effect as much as phytocannabinoids.

Why terpenes matter: CBDay Plus uniquely designed terpene profile

Choosing terpenes for one’s genetics means consciously orienting it toward certain properties and therapeutic qualities. Nowadays, terpenes have taken the center stage of Cannabis breeding and are finally getting the attention they deserve.

Each cannabis strain has its own terpene profile. 

CBDay Plus is designed for daily stress recovery. In order of percentages, the sativa hemp genetics from which it is extracted contain the following terpenes:

Beta caryophyllene

a very special terpene that can directly activate the CB2 receptor of the endocannabinoid system, thus acting as if it were a cannabinoid.

It features a unique structure since it contains a rare cyclobutene ring that is not found in any other cannabis terpene.

Beta-caryophyllene has potent anti-inflammatory properties, especially at the cerebral (reducing chemicals that cause oxidative stress associated with inflammation) and intestinal levels.

In addition, it can reduce inflammation related to multiple sclerosis and immune system dysfunction, can help reduce pain related to the nervous system, and provide topical pain relief in creams and unguents because it acts as a local anesthetic. It can release the same endorphins as morphine without being addictive. 

The interaction of CBD and Beta Caryophyllene may be a potential additional treatment for substance abuse/dependence. Humulene and Beta Caryophyllene interaction, on the other hand, may have anti-inflammatory properties that make it practical for the treatment of arthritis, bursitis, and fibromyalgia.

Nerolidol

When combined with cannabis, the aroma and properties of nerolidol can produce a calming effect, and Blue Dream and GG4 are two cannabis strains that exhibit this effect.

It has antifungal, antibacterial, anti-inflammatory, anxiolytic and antioxidant properties, but the most important function is calming-sedative. The most scientifically known effect is that it improves skin absorption without irritating the skin, making it a powerful ally for taking certain medications, also being one of the few nontoxic and extremely functional alternatives.

Recent tests have shown that it can positively affect brain activity, through an anxiolytic effect and a neuroprotective effect against oxidative stress on neurons. Finally, lately, it is much considered for its anti-parasitic properties, inhibiting their growth, and especially for its antimalarial action.

Alpha Humulene

A very effective terpene commonly used in ancient Chinese and Asian medicine. It is often found in b-caryophyllene-rich genetics. With the latter, in fact, it shares the chemical formula while differing in structure. 

Recent studies hint at its strong antitumor action, as, combined with other phytocannabinoids, it inhibits cancer cells. This is due to its ability to produce Reactive Oxygen Species, leading to an antineoplastic effect that induces apoptosis. In high dosages and in the presence of chronic inflammation, however, it can cause an increase in tumor growth.

Other studies demonstrate its antibacterial properties, mainly against Staphylococcus aureus when administered in low dosages, and analgesic and anti-inflammatory properties, both systemic and topical. 

Alpha Humulene plays an important role in pharmacokinetics, as it is showing potential in rapid distribution throughout the body, both orally and topically. 

Finally, it exhibits hunger-suppressing action, which is useful in the treatment of some eating disorders.

Bisabolol

Not your typical cannabis terpene, it is considered the terpene of chamomile, since the latter’s flowers are loaded with it.

Recently it has attracted much attention for its bactericidal and fungicidal action, both in cosmetics and foods and as a component of antifungal products.

It also antagonizes oxidative stress caused by the fungus Candida albicans and is effective against some liver and spleen bacteria. 

Research has focused heavily on its response to inflammatory action, especially of the skin, endogenous or caused by external elements or substances. Also in the inflammatory field, it is used with positive results as an analgesic.

Anti-ulcer and gastroprotective properties have also been demonstrated, as it has the ability to protect the gastric lining from ethanol-induced ulcers. In addition to its antioxidant action, like almost all terpenes, bisabolol promotes apoptosis of leukemic cells, going directly to damage the mitochondrial integrity of dysfunctional cells, causing their death. 

Although it turns out to have anxiolytic properties and to be effective against neuropathic pain, the most important properties are gastroprotective and anti-inflammatory, especially cutaneous.

Coming full circle: CBDay Plus’ effects, the power of an actual full spectrum extract

First, it should be noted that each endocannabinoid system is different and each responds to phytocannabinoids and terpenes in different ways and with varying degrees of intensity.

That said, the composition of CBDay plus allows for the intake of a perfectly balanced product that brings the consumer a wide range of effects and a thorough therapeutic experience. 

However, most of the effects will be initially non-obvious, as all the preventive properties act in silence by rebalancing our system from within.

Certainly the predominant and most noticeable effect is the sedative-calmative one, but it depends a lot on the amount taken and especially the concentration of CBDay plus: 5%-10%-15%.

Each one caters to a different consumer and reacts with different intensity with her endocannabinoid system.

CBDay Plus 5% is recommended for consumers less accustomed to taking CBD and cannabinoids in general. In fact, an endocannabinoid system that is not accustomed to phytocannabinoids can reap plenty of benefits and an encompassing therapeutic experience even at the lowest concentration. Relaxing, anti-stress and calming effects will be prevalent, with little sedative potency.

CBDay Plus 10% is recommended for consumers who are already familiar with phytocannabinoids or those who need to address more intense and complex, often chronic, problems. The therapeutic efficacy is much more relevant, with similar effects to 5% but with much stronger sedative potency, unless the consumer has a lot of tolerance and needs higher dosages. It will certainly have a strong anti-stress, anxiolytic and balancing effect, both physically and psychologically. Also recommended to facilitate rest and improve sleep cycles.

CBDay Plus 15% on the other hand, is for more accustomed users with previous experience in CBD and cannabinoid consumption. It is definitely the product that gives the most comprehensive therapeutic experience, having higher values of cannabinoids and terpenes adding to a much stronger entourage effect. It is especially recommended for more stressed individuals with irregular and unsatisfactory sleep cycles. It allows one to live the day lighter and more rested as one’s endocannabinoid system works to rebalance our body’s mechanisms. It can be overly strong for new or unaccustomed users.

References

CBG

1. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on
experimental inflammatory bowel disease
https://www.sciencedirect.com/science/article/abs/pii/S0006295213000543?via%3Di
hub
2. A Comparison of the Ocular and Central Effects of Δ9-Tetrahydrocannabinol and
Cannabigerol

https://www.liebertpub.com/doi/10.1089/jop.1990.6.259
3. Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in
R6/2 Mice and 3-Nitropropionate-lesioned Mice
https://link.springer.com/article/10.1007/s13311-014-0304-z
4. Uncovering the Hidden Antibiotic Potential of Cannabis
https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00419
5. Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant
Crypt Foci (ACF) and Tumor Volume: A Systematic Review
https://www.hindawi.com/journals/ecam/2020/2371527/

CBN

ScienceDirect: “Cannabinol.”
https://www.sciencedirect.com/topics/neuroscience/cannabinol
National Institutes of Health: “Cannabis (Marijuana) and Cannabinoids: What You
Need To Know.”
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders: “Cannabinol
delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival.”
https://pubmed.ncbi.nlm.nih.gov/16183560/
Archives of Oral Biology: “Cannabidiol, cannabinol and their combinations act as
peripheral analgesics in a rat model of myofascial pain.”
https://pubmed.ncbi.nlm.nih.gov/31158702/

CBC

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid
extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417459/#:~:text=Cannabichromene
%20(CBC)%20is%20a%20major,TRPA1%20may%20modulate%20gastrointestinal
%20motility.
Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of
Cannabidiol on Human Breast Carcinoma
https://jpet.aspetjournals.org/content/318/3/1375.long
Pharmacological Evaluation of the Natural Constituent of Cannabis Sativa,
Cannabichromene and its Modulation by Δ9-Tetrahydrocannabinol*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967639/
The effect of cannabichromene on adult neural stem/progenitor cells
https://pubmed.ncbi.nlm.nih.gov/23941747/
Differential effectiveness of selected non-psychotropic phytocannabinoids on human
sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne
treatment
https://pubmed.ncbi.nlm.nih.gov/27094344/
Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids
isolated from Cannabis sativa L
https://pubmed.ncbi.nlm.nih.gov/20332000/

Beta Caryophillene

PipeNig®-FL, a Fluid Extract of Black Pepper (Piper Nigrum L.) with a High

Standardized Content of Trans-β-Caryophyllene, Reduces Lipid Accumulation in
3T3-L1 Preadipocytes and Improves Glucose Uptake in C2C12 Myotubes
https://www.mdpi.com/2072-6643/11/11/2788
β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a
Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-
19
https://www.frontiersin.org/articles/10.3389/fphar.2021.590201/full
ScienceDirect – Caryophyllene
https://www.sciencedirect.com/topics/medicine-and-dentistry/caryophyllene
β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice
Through a Cross-Talk between CB2 and PPAR-γ Receptors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723248/
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury
via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in
Vitro
https://www.frontiersin.org/articles/10.3389/fnins.2017.00583/full
Inhibitory effects of β-caryophyllene on Streptococcus mutans biofilm
https://pubmed.ncbi.nlm.nih.gov/29407750/
Use of β-caryophyllene to combat bacterial dental plaque formation in dogs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045627/
Inhibitory Effects of β-caryophyllene on Helicobacter pylori Infection: A
Randomized Double-blind, Placebo-controlled Study
https://synapse.koreamed.org/articles/1135713

NEROLIDOL

Antifungal effect of eugenol and nerolidol against Microsporum gypseum in a guinea
pig model
https://pubmed.ncbi.nlm.nih.gov/17202684/
Nerolidol Suppresses the Inflammatory Response during Lipopolysaccharide-Induced
Acute Lung Injury via the Modulation of Antioxidant Enzymes and the AMPK/Nrf-
2/HO-1 Pathway
https://pubmed.ncbi.nlm.nih.gov/31827712/
Antileishmanial Activity of the Terpene Nerolidol | Antimicrobial Agents and
Chemotherapy
https://journals.asm.org/doi/full/10.1128/aac.49.5.1679-1687.2005
Sensitization of Staphylococcus aureus and Escherichia coli to Antibiotics by the
Sesquiterpenoids Nerolidol, Farnesol, Bisabolol, and Apritone
https://www.royalqueenseeds.it/blog-terpeni-della-cannabis-nerolidoloun-versatile-
sesquiterpene-n1188
Antimalarial activity of the terpene nerolidol.
https://www.ncbi.nlm.nih.gov
Assessment of anxiolytic effect of nerolidol in mice
https://www.ncbi.nlm.nih.gov
Antioxidant effects of nerolidol in mice hippocampus after open field test
https://www.ncbi.nlm.nih.gov
The effect of terpene concentrations on the skin penetration of diclofenac sodium.
https://www.ncbi.nlm.nih.gov
Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress
induced by rotenone
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994214/

HUMULENE

Composition and Antibacterial Activity of Abies Balsamea Essential Oil
https://www.ncbi.nlm.nih.gov
Antitumor Activity of Balsam Fir Oil: Production of Reactive Oxygen Species
Induced by Alpha-Humulene as Possible Mechanism of Action
https://www.ncbi.nlm.nih.gov
Anti-inflammatory Effects of Compounds Alpha-Humulene and (-)-Trans-
Caryophyllene Isolated From the Essential Oil of Cordia Verbenacea
https://www.ncbi.nlm.nih.gov
Preventive and therapeutic anti-inflammatory properties of the sesquiterpene α-
humulene in experimental airways allergic inflammation
https://www.ncbi.nlm.nih.gov
ScienceDirect – Humulene
https://www.sciencedirect.com/topics/medicine-and-dentistry/humulene
Pharmacokinetics and tissue distribution of the sesquiterpene a-humulene in mice
https://www.sciencedirect.com/topics/medicine-and-dentistry/humulene

BISABOLOL

Fungicidal and Bactericidal Properties of Bisabolol and Dragosantol
https://www.tandfonline.com
Chemical Composition, Antibacterial, Antifungal and Antioxidant Activities of
Algerian Eryngium Tricuspidatum L. Essential Oil
https://www.ncbi.nlm.nih.gov
Antioxidant Activity of Bisabolol: Inhibitory Effects on Chemiluminescence of
Human Neutrophil Bursts and Cell-Free Systems
https://www.ncbi.nlm.nih.gov
The Antimicrobial Activity of Alpha-Bisabolol and Tea Tree Oil Against
Solobacterium Moorei, a Gram-positive Bacterium Associated With Halitosis
https://www.ncbi.nlm.nih.gov
α-(-)-Bisabolol Reduces Pro-Inflammatory Cytokine Production and Ameliorates
Skin Inflammation
https://www.ncbi.nlm.nih.gov
Anti-nociceptive and Anti-Inflammatory Activities of (-)-α-Bisabolol in Rodents
https://www.ncbi.nlm.nih.gov
Gastroprotection of (-)-Alpha-Bisabolol on Acute Gastric Mucosal Lesions in Mice:
The Possible Involved Pharmacological Mechanisms
https://www.ncbi.nlm.nih.gov
Randomized, Controlled Study of Innovative Spray Formulation Containing
Ozonated Oil and α-Bisabolol in the Topical Treatment of Chronic Venous Leg
Ulcers
https://www.ncbi.nlm.nih.gov

Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute
leukemia cells
https://translational-medicine.biomedcentral.com